Dystrophic neurites labelled by pre-autophagosomal proteins in Alzheimer’s brains
نویسندگان
چکیده
منابع مشابه
Reduced amyloid deposition in mice overexpressing RTN3 is adversely affected by preformed dystrophic neurites.
Reticulon 3 (RTN3) was initially identified as a negative modulator of BACE1, an enzyme that cleaves amyloid precursor protein (APP) to release beta-amyloid peptide. Interestingly, RTN3 can also form aggregates after accumulation, and increased RTN3 aggregation correlates with the formation of RTN3 immunoreactive dystrophic neurites (RIDNs) in brains of Alzheimer's cases. Transgenic mice expres...
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Neuritic dystrophy is one of the important pathological features associated with amyloid plaques in Alzheimer's disease (AD) and age-dependent neuronal dysfunctions. We reported previously that reticulon-3 (RTN3) immunoreactive dystrophic neurites (RIDNs) are abundantly present in the hippocampus of AD patients, in AD mouse models, and in aged wild-type mice. Transgenic mice overexpressing the ...
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ژورنال
عنوان ژورنال: Molecular Psychiatry
سال: 2019
ISSN: 1359-4184,1476-5578
DOI: 10.1038/s41380-019-0476-3